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Obstructive sleep apnea quietly destroys memory, motivation, and even marriages. Jobs are lost, promotions delayed, and relationships strained. Performance and workplace safety is threatened, as is the ability to excel where the now-sleep-deprived once thrived.
In Freedom from CPAP: Sleep Apnea Hurts, the Cure Doesn’t Have To, authors and doctors David Dillard and Mayoor Patel have teamed up to provide a uniquely comprehensive overview of sleep apnea from both an ENT and a dental perspective.

• Sales Rank: #115286 in eBooks
• Published on: 2015-04-03
• Released on: 2015-04-03
• Format: Kindle eBook

Most helpful customer reviews

9 of 9 people found the following review helpful.
Sleep better, Feel better, Live longer
By JB1224
A lot of good accurate information written so that non-doctors can understand it. I am a dentist who helps treat sleep apnea patients, and I plan to keep a few copies in my office to let patients read.

9 of 10 people found the following review helpful.
If you don't get along with your CPAP
By Prentiss Fontaine
Dr.s Patel and Dillard absolutely nailed it. You have options, and most physicians will conveniently leave out the options detailed in this book, even though there are rigorous studies showing efficacy of non-CPAP options. If you have been given a CPAP and do not use it all night every night, you owe it to yourself to get educated on the alternatives, and this book is a great start. Don't leave your sleep apnea untreated! Dr. Kent Smith www.SleepDallas.com

4 of 5 people found the following review helpful.
I would highly recommend this unique book to individuals as well as health ...
By Dr. B. Fareid
As a practitioner in the field of sleep apnea treatment, I would highly recommend this unique book to individuals as well as health care professionals who deal with sleep apnea and wish to have an informative book to be presented to their patients.

It is indeed well written by the experts in the field and is enjoyable to read. This book to my belief is the most comprehensive, concise, informative, valuable and easy-to-read book which in reality summarizes all risks associated with sleep apnea and the corresponding treatment options.

An excellent source of information and reference. The best of its kind!

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[C393.Ebook] PDF Download Handbook of Immunological Properties of Engineered Nanomaterials (Frontiers in Nanobiomedical Research), by Marina A Dobrovolskaia, Scott

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The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.

The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Readership: Researchers, academics, undergraduates and graduates in toxicology, immunotoxicology and nanomedicine, and industry (small and mid biotech companies and big pharmaceutical companies), as well as regulatory agencies (EPA, FDA) and physicians.

• Sales Rank: #3414244 in Books
• Brand: Brand: World Scientific Publishing Company
• Published on: 2013-02-21
• Original language: English
• Number of items: 1
• Dimensions: 9.80" h x 1.30" w x 6.60" l, .0 pounds
• Binding: Hardcover
• 720 pages

Features

• Used Book in Good Condition

Review
"Understanding the immunogenicity of novel, engineered nanoparticle-based drugs is absolutely critical in bringing a nanomedicine into the clinic. Nanomedicines may activate the immune system or be invisible to it; the choice depends on the application. But regardless, the mechanism of nanoparticle immune interaction needs to be well understood and controlled. And this Handbook is an absolutely essential reference for those designing, developing, or testing novel nanomedicines." -- Lawrence Tamarkin, President & CEO, CytImmune
"One of the most overlooked areas in nanomedicine development is the study of the interaction of the host immune system with these novel constructs. Recognizing that the immune system has evolved over millennia to eliminate threats in the form of pathogenic organisms that are often in the nano range, it is imperative that scientists and developers of nanomaterials engineered for in vivo use, understand this formidable barrier while trying to exploit the field. Dobrovolskaia and McNeil have put together an impressive collection of must-read chapters from experts that should inform motivated nanotechnologists and provide a roadmap to avoid major stumbling blocks in efforts to develop new nanomedicines. I wish I had such a guide to refer to during the early development of Abraxane." -- Neil Desai, Inventor, Abraxane and the nab-platform, Abraxis Bioscience, a wholly owned subsidiary of Celgene Corporation

"The interesting data and objectives reported in all the chapters can improve and inspire research ideas and topics to expert clinicians as well as to material and mechanical engineers, biomedical engineers, molecular cell biologists, physiologists and students also of both the chemical and medical community." -- Journal of Applied Cosmetology

"One of the most overlooked areas in nanomedicine development is the study of the interaction of the host immune system with these novel constructs. Recognizing that the immune system has evolved over millennia to eliminate threats in the form of pathogenic organisms that are often in the nano range, it is imperative that scientists and developers of nanomaterials engineered for in vivo use, understand this formidable barrier while trying to exploit the field. Dobrovolskaia and McNeil have put together an impressive collection of must-read chapters from experts that should inform motivated nanotechnologists and provide a roadmap to avoid major stumbling blocks in efforts to develop new nanomedicines. I wish I had such a guide to refer to during the early development of Abraxane." --Neil Desai, Inventor, Abraxane and the nab-platform, Abraxis Bioscience, a wholly owned subsidiary of Celgene Corporation

From the Inside Flap
The Handbook of Immunological Properties of Engineering Nanomaterials provides a comprehensive overview of current literature, methodologies, translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is immunological properties of engineered nanomaterials. The focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, Dendritic cells, complement and coagulation systems, interaction with plasma proteins, nanoparticle sterility and sterilization. Each chapter includes a comprehensive literature review of a given area; describes protocols and resources available to support research in individual focus area; highlights challenges; and outlines unanswered questions and future directions. In addition, the handbook provides an overview and a practical guide to physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles.

The handbook also reviews regulations related to immunotoxicity testing of materials prior to their translation into clinic. It is written by top experts in the field of nanomedicine, nanotechnology and translational bionanotechnology representing academia, government, industry, consulting organizations and regulatory agencies. The handbook is designed to serve as a textbook for students, a practical guide for research laboratories and an informational resource for scientific consultants, reviewers and policy makers. It is written such that both experts and beginners will find useful information.

About the Author
Marina Dobrovolskaia is a Senior Scientist at the Nanotechnology Characterization Laboratory of SAIC-Frederick Inc., a contractor to the National Cancer Institute at Frederick. She directs preclinical in vitro and in vivo immunological characterization of engineered nanomaterials. Dr Dobrovolskaia is also responsible for the development, validation and performance qualification of in vitro and ex vivo assays to support preclinical characterization of nanoparticles, and for monitoring nanoparticle purity from biological contaminants such as bacteria, yeast, mold and endotoxin. Additionally, she leads structure activity relationship studies aimed at identifying the relationship between nanoparticle physicochemical properties and their interaction with macrophages, components of the blood coagulation cascade, and complement system. Prior to joining NCL she worked as a Research Scientist in a GLP laboratory at PPD Development, Inc. in Richmond, VA, where she was responsible for the design, development and validation of bioanalytical ligand-binding assays to support pharmacokinetic, toxicity and immunogenicity studies in a variety of drug development projects. She received her MS degree from the Kazan State University in Russia, her PhD from the N N Blokhin Cancer Research Center of the Russian Academy of Medical Sciences in Moscow, Russia, and completed two postdoctoral trainings in immunology at the National Cancer Institute in Frederick, MD and the University of Maryland in Baltimore, MD. Her areas of expertise include cell signaling, innate immunity, immunogenicity, endotoxin and analytical methodology.

Dr McNeil serves as the Director of the Nanotechnology Characterization Laboratory (NCL) for SAIC–Frederick and the National Cancer Institute at Frederick (NCI-Frederick), where he coordinates preclinical characterization of nanotech cancer therapeutics and diagnostics. At the NCL, Dr. McNeil leads a team responsible for testing of candidate nanotech drugs and diagnostics, evaluating safety and efficacy, and assisting with product development — from discovery–level, through scale-up and into clinical trials. NCL has assisted in characterization and evaluation of more than 200 nanotechnology products, several of which are now in human clinical trials. Dr McNeil is a member of several working groups on nanomedicine, environmental health and safety, and other nanotechnology issues. He is an invited speaker to numerous nanotechnology-related conferences and has several patents pending related to nanotechnology and biotechnology. He also directs SAIC-Frederick's Imaging and Nanotechnology Group (ING), and is a Vice President of SAIC-Frederick. Prior to establishing NCL, he served as Senior Scientist in the Nanotech Initiatives Division at SAIC where he transitioned basic nanotechnology research to government and commercial markets. He advises Industry and State and US Governments on the development of nanotechnology and is a member of several governmental and industrial working groups related to nanotechnology policy, standardization and commercialization. Dr McNeil's professional career includes tenure as an Army Officer, with tours as Chief of Biochemistry at Tripler Army Medical Center, and as a Combat Arms officer during the Gulf War. He received his bachelor's degree in chemistry from Portland State University and his doctorate in cell biology from Oregon Health Sciences University.

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Tests of Skill v.3.5 is thoroughly revised, updated, and expanded version of the innovative OGL adventure module and sourcebook originally released as a version 3.0 publication and intended as a companion volume to Experts v.3.5. This edition has been expanded by 24 pages, had its character and monster stats corrected and revised, and had added to it one new encounter, one new scenario, one new scenario outline, a section on Defects and how to use them in the game, and numerous other elements. It is intended to be enjoyed both by people familiar with the previous version and those completely new to it. Tests of Skill v.3.5 is designed to entertain and challenge players through scenarios and encounters that can be overcome optimally through role-playing, skill use, and diplomacy. While traditional hack-and-slash techniques can be used to complete portions of the scenarios, most groups will find that tact, thought, and appropriate use of skills, feats, and abilities are generally much more useful and effective. It includes numerous tips on adjudicating skill checks that can be applied to any game session. Features include: • A versatile wild-land setting — the Silurian Heights — that can be used as a campaign setting or easily dropped into almost any existing milieu, including statistics on six different urban areas and local weather. • More than two dozen detailed encounters, including three complete mini-dungeons and general and specific encounter tables. • Three detailed scenarios and three scenario outlines that explain how to organize the included encounters into effective plot lines. • 10 maps and diagrams, including player’s and DM’s wilderness maps, diagrams of several encounter areas, and a dungeon map based on Dwarven Forge’s Master Maze sets. • Dozens and dozens of fully keyed and described NPCs, including two complete adventuring parties and stats for sample Warriors, Commoners, and Experts of the types like to be encountered. • Three new prestige classes, the Gnoll Crocuta (plus the new Fear spell domain), Humbug, and Mercenary Commander. • 16 new Skills, 35 new Feats, and 19 new Defects. • Three new monsters, the Half Troll, Dire Hyena, and Multi-Mind. • Detailed rules on the creation, usage, and special properties of books, including their effects on XP and skill checks.

• Published on: 2015-04-24
• Original language: English
• Number of items: 1
• Dimensions: 11.00" h x .30" w x 8.50" l, .71 pounds
• Binding: Paperback
• 130 pages

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This is the official curriculum of Apple’s Mavericks 201: OS X Server Essentials 10.9 course and preparation for Apple Certified Technical Coordinator (ACTC) 10.9 certification–as well as a top-notch primer for anyone who needs to implement, administer, or maintain a network that uses OS X Server on Mavericks. This book provides comprehensive coverage of OS X Server and is part of the Apple Pro Training series–the only Apple-certified books on the market. Designed for help desk specialists, technical coordinators, and entry-level system administrators, this guide teaches you how to install and configure OS X Server on Mavericks to provide network-based services. You’ll also learn to use tools for efficiently managing and deploying OS X Server. In addition to learning key concepts and experiencing hands-on, practical exercises throughout, the book also covers the learning objectives to help you prepare for the industry-standard ACTC certification.

•�� �Provides authoritative explanations of OS X Server setup and management on Mavericks.
•�� �Focused lessons take you step by step through practical, real-world exercises.
•�� �Lesson review questions summarize what you learn to prepare you for the Apple certification exam.
•�� �Lesson files available for download.

• Sales Rank: #1133963 in Books
• Published on: 2014-01-05
• Original language: English
• Number of items: 1
• Dimensions: 9.15" h x 1.30" w x 7.45" l, 2.25 pounds
• Binding: Paperback
• 624 pages

About the Author
Arek Dreyer (Chicago, IL) has been an Apple Certified Trainer since 2002. President of Dreyer Network Consultants Inc. in Chicago, Arek delivers courses and provides training around the world, both in the classroom and at events like the MacIT� Conference and European Macintosh System Administrators Meetings. Arek provides consulting, troubleshooting, and integration services for customers that use iOS devices and Macs in complicated environments.

Ben Greisler (Exton, PA) is the owner and technical lead of Kadimac Corp., a firm specializing in the integration of iOS and OS X into enterprise IT settings. Ben is an Apple Certified Trainer, author, consultant, and lecturer who has served on the Advisory Councils of the Apple Consultants Network and MacIT� Conference. Together Arek and Ben have collaborated to write several titles in the Apple Pro Training Series including OS X Server Essentials for Mountain Lion.

Most helpful customer reviews

1 of 1 people found the following review helpful.
Constant companions for new OS X Server versions
By Michael J. Oneill
I buy each series of these and they're always a perfect companion for walking through a new mac server version for the first time. Just install Parallels and a fresh OS & Server App and go to town. Its that easy to learn.

1 of 1 people found the following review helpful.
Good introduction to Mac server
By freedomforall
I am a Windows computer service professional, wanting to broaden my market, so I am getting myself familiar with the Mac world. This book gives a good introduction to the Mac server possibilities and how to configure it.

5 of 8 people found the following review helpful.
Written for the class - not for individuals
By Scott D. Kelly
If you're enrolled in the Apple course, this books is likely very helpful, but if you're an individual looking for a "how-to" resource to guide you through configuring OSX Server for your own network, this book is a far cry from what you're looking for. All instructions are written for the in-class network environment that Apple uses for their instructor-led Certified Technical Coordinator course. If there's information in here about how to configure a server in the real world, I can't find it. Best to rely on online user forums or maybe another text unless you're sitting in an Apple classroom.

See all 7 customer reviews...

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He Restores My Soul: Gentle Whispers of God's Loving Care

• Sales Rank: #221404 in Books
• Brand: Brand: Harvest House Publishers
• Published on: 2000-08
• Original language: English
• Number of items: 1
• Dimensions: .47" h x 11.15" w x 9.09" l,
• Binding: Hardcover
• 80 pages

Features

• Used Book in Good Condition

Most helpful customer reviews

3 of 3 people found the following review helpful.
a testimony of the love of our Savior
By Wilma Tarro
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Book rating
By LUELLA LAFAYETTE
I really loved this book. The pictures were great and also the words were very encouraging and spiritually uplifting. It just wasn't a book with pretty pictures but the author had some spiritual depth showing how he understands the bible.

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• Sales Rank: #4413158 in Books
• Published on: 2008
• Number of items: 2
• Binding: Hardcover

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This touching collection of inspirational thoughts focuses on the true meaning of faith in our ordinary lives. Newly repackaged and redesigned, Faith Is... classically defines our powerful belief in Jesus Christ. Its simple format and delivery of biblical truths has made it a favorite gift for more than thirty years.


From the Hardcover edition.

• Sales Rank: #1210056 in Books
• Published on: 1994-04-01
• Released on: 1994-04-01
• Original language: English
• Number of items: 1
• Dimensions: 4.50" h x 6.25" w x .50" l,
• Binding: Paperback
• 1 pages

About the Author
Dr. Pamela Reeve is a popular author, conference speaker, and advisor and professor at Multnomah Bible College and Seminary in Portland, Oregon. Formerly the dean of women at Multnomah, Dr. Reeve has written the bestseller Faith Is . . . (more than one million copies sold) as well as Parables of the Sea (over a quarter million volumes sold) and Parables of the Forest. She also authored the booklet Relationships, Multnomah's all-time bestseller in the popular Vital Issues series.


From the Hardcover edition.

Most helpful customer reviews

11 of 11 people found the following review helpful.
Faith Is
By Wendy A. Johnson
This book is a powerhouse of reminders for us of God's love and desire to heal, help, lift and restore our lives. Pamela Reeve gets this done in a most beautiful way. It will be a comfort and inspiration to anyone blessed to read it. You will be inspired to seek and receive's God's love after reading just a few passages.

8 of 9 people found the following review helpful.
Uplifting synopsis of what it means to trust God.
By Jan Thackston (thacksj@mpinet.net
This is one of the most inspiring "little" books I've read to date. Pamela Reeve, in one or two sentences per page, reveals the true meaning of Faith in God. It is a "must read" for Christians. Need a gift for that person who has everything? This small, inexpensive book, has the potential to change lives and will be a treasure to the recipient. I know. A friend gave me my copy.

5 of 5 people found the following review helpful.
This book confirms that faith is the conduit to knowing God
By MISSY@GATEWAY.NET
Pamela Reeve shows to the believer, and those who aren't, that faith is truly the substance of things we hope for and the evidence of things we don't see...From feeling sorry for oneself to pulling it together through faith to climbing the rugged mountain of life to the sweet taste of victory, Ms. Reeve has an answer to it all--FAITH!!!!

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In and out of the bedroom, Alex and Angel's passion is an all-consuming, every-second-of-every-day, can't-stop-thinking-about-you, obsession! They have it all; fiery hot sexual chemistry, an undeniable mental connection, a profound emotional bond, and a newfound trust as they promise each other, "no more secrets". Theirs is a sensual, magical love affair of epic proportions. When their perfect world is shaken by a dangerous criminal out to extract painful revenge on them, the fierce protectiveness that rules Alex becomes a single purposed objective that will drive him beyond his limits and make him do things even he didn't know he was capable of. Experience one of the hottest couples in contemporary romantic fiction in the heart-pounding, dangerous and sexy conclusion to Kahlen Aymes' After Dark Series!

• Sales Rank: #37704 in Audible
• Published on: 2016-01-11
• Format: Unabridged
• Original language: English
• Running time: 738 minutes

Most helpful customer reviews

11 of 11 people found the following review helpful.
~~ 4.5 Alexander Avery Stars ~~
By Jennifer H.
I am going to seriously miss Alex and Angel. They have to be one of my all time favorite book couples. I LOVED them from the very first book (Angel After Dark) to the last book (Promises After Dark). If you like a book/series that has everything…then this is the series you NEED to pick up and read.

This is the third book in the series, but just like the other two, it has everything you want in a book. We got love and romance, HOT sexy scenes, and suspense and intrigue. I was happy to see that we really didn't have heartbreak in this book when it came to Angel and Alex. I loved how they worked everything out together :) This book will be hard for you to put down. I know my stomach was in my throat and my heart was in my stomach for a good part of this book. There were some unanswered things after book two (Confessions After Dark) but rest assured everything is answered and put to rest in this book. I am not going to say much about the plot of this book, because I really think it would spoil both book two and three. Just know that this book takes off right where book 2 ended. There is no time lost.

Again, as was the same in book 1 and 2, the writing was flawless. Kahlen created a story that sucked you in and didn't let go until the very end. You can't turn the pages fast enough when it comes to this book. The only reason I didn't give this a full 5 stars like the other two books, was because I thought the beginning was a little slow and that there was some over detailing. I think some things could've been cut out to shorten the book and nothing would've been lost or missing. But that didn't deter me from fully enjoying this book/series. This is definitely one that I will read again and again and has a place on my favorites shelf at home :)

I will say that this book was NOT an easy journey for Alex and Angel. They had some serious things to overcome in this book. Both needed to learn to trust each other and believe in each others love. They truly were tested in this book, but like I said I am glad they got through it all together!!!! I was extremely happy to see that Angel was back to the character I liked in book 1….I felt she lost herself a little in book 2 and was a little too whiny, but thankfully she wasn't like that in this book. Alex was his normal dreamy self but even better….if that's possible!!!! I was glad we got to see more of Cole (Alex's brother) and Becca and Jillian (Angel's BFF and Becca's daughter) I even think that Kahlen hinted at something happening between Becca and Cole….maybe there will be a spinoff for these two characters. I think their story would be great :)

Again I would recommend this book to everyone who has read book 1 ( Angel After Dark ) and book 2 (Confessions After Dark), and is also a fan of Kahlen Aymes. Heck even if you aren't a fan or have never heard of her before….. READ THIS SERIES!!!!!
You definitely want to meet Angel and Alex and follow them on their wonderful journey to happiness!!!

10 of 10 people found the following review helpful.
What are you waiting for??? Get this series!!!!
By Dawn Morrison
I cannot say enough about Kahlen Aymes and her crazy, talented writing that she does! I have loved this series since first being introduced to Alex and Angel when book 1 came out. Kahlen has done it again with Promises. I literally could not stop reading. I just kept thinking, "One more chapter" but I just couldn't find a stopping place. Angel isn't a mousy doormat but a successful doctor, sassy and takes no crap kind of woman. Alex is uber male and possessive of his woman. Their sexual chemistry is out of this world and the bedroom scenes are whew! Hot! I love the suspense in the story of this psychopath that is after Angel. Not to give any spoilers but there is a situation that literally had me feeling the fear and anxiousness of the characters in the book. That my friend, is what you call fantastic writing!!! I will buy anything that Kahlen writes because she is just that good! Superb wrap up of the series. I am hoping she will write Cole and Becca's story. It would also give us little glimpses of Alex and Angel's lives through Cole and Becca's story but I am just really interested in where their story could go. Please Kahlen, write theirs! Jillybean deserves a great love story for her Mommy! Don't hesitate to one click this book. You are CRAZY if you don't. Do not miss out on this amazing, hot, sexy, suspenseful series. Click now!!!!!!

13 of 14 people found the following review helpful.
Amazing conclusion, to an amazing series!!
By Simone
Promises After Dark is the third book in the After Dark series, and WOW did this conclusion really go out with a bang!! I have loved following Angel and Alex's passionate, fiery, relationship through this series. Angel has a strong, almost alpha male, take no crap personality and Alex's caveman, hot headed personality wrapped up in a sex god of a man, that would make any woman's ovaries explode with one quick glance. Put Alex and Angel together and it's like fireworks going off in all directions.

This book took me on one roller coaster of emotions. There were many a time the twist and turns in this book took my breath away while holding it in the next with the suspense and plot twists. There is so much that is going on in this story, I could not stop turning the pages wanting to know what was going to happen next. Kahlen really has a great writing style that grips you tight, makes you fall in love with the characters, plot lines that are well developed, bedroom scenes that will leave you wanting to leave the room to cool yourself down, but then rushing back to indulge in some more. If you thought Alex was hot before, he just turned it up a notch in this last instalment and has gone all out for us ladies, and boy what a finale.

I found myself so engrossed in this story I was frantically trying to get to the end to find out if Alex and Angel got their HEA because jeez, if one couple deserved it, it was them.I mean how much can a couple take? But that just made me love them both even more. The risks they took, the never giving up on their friends and each other. Each obstacle that got in their way, every spanner that got thrown in their direction just made them more stronger and determined to be together and make sure everyone was safe.

That just leaves me to say Kahlen Aymes has done it again. Another amazing series that deserves 5 stars from me. I am also hoping Cole and Becca get a story of their own as I could do with another hot Avery brother to spend some time with to help get me over my Alex withdrawals.
I recommend The After Dark Series to anyone who adores Kahlen's books as much as I do or, if your looking for a sexy, romantic read with added thrills, suspense and a great story line running through it, this is the series for you.

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